Cenegenics is excited for the launch of the reformulated Comprehensive Multi-Vitamin & Mineral Formula. A new exciting feature of Cenegenics Comprehensive Multi-Vitamin & Mineral is the formula’s aim towards improving insulin sensitivity to optimize a number of age-related risk factors.

If you are one of the many Americans caught in the standard American diet that is low in fruits and vegetables and high in processed foods, vital nutrients that stabilize energy and immunity are being depleted from your body. Dietary imbalances can weaken your body’s resistance to illness and degenerative ailments. Make sure your body is getting essential nutritional support with Cenegenics Comprehensive Multi-Vitamin & Mineral Formula, which includes essential vitamins and minerals to help balance your daily nutritional needs.

Cenegenics Comprehensive Multi-Vitamin & Mineral Formula supports a healthy environment for the heart, muscles, bones, and skin, while also enhancing nerve function, digestion, immune function, cellular repair, and improving insulin sensitivity.

Improving and sustaining insulin sensitivity regularly with combined nutrition, exercise, and nutraceutical strategies can help:

• Improve fat loss potential
  
• Aid with cravings on the daily basis
  
• Reduce inflammation 
  
• Fight cognitive decline
  
• Reduce risk of age-related diseases

Whether you’re trying to improve micronutrient intake, optimize insulin sensitivity, or reduce inflammation, Cenegenics Comprehensive Multi-Vitamin & Mineral formula is a great tool for improving your overall health.

Manufactured in the U.S.A.

DIRECTIONS: As a dietary supplement, take one packet daily, or as directed by a physician.

Children, pregnant or lactating women, and individuals using blood thinners should consult their physician prior to use. Do not use if tamper seal is damaged.

STORAGE: Keep tightly closed in a cool, dry place out of reach of children.

PRECAUTIONS

The maximum safe dosages of the nutrients in this formula have not been determined for children, pregnant or nursing women, or those with severe liver or kidney disease. As with all supplement regimens, please consult your physician prior to use.

Supplement Facts:

Vitamin A (75% as natural beta-carotene and 25% as retinyl palmitate) - 1,680.00 mcg

Vitamin C (as sodium ascorbate, potasium ascorbate, zinc ascorbate, and calcium ascorbate) - 187.50 mg

Calcium (as DimaCal® di-calcium malate, d-calcium pantothenate, and calcium ascorbate) - 75.00 mg

Vitamin D3 (cholecalciferol) - 150.00 IU

Vitamin E (as d-alpha tocopherol) - 33.50 mg

Vitamin E (as d-alpha tocopheryl succinate and mixed tocopherols) - 100.50 mg

Thiamin (as thiamine mononitrate) - 15.00 mg

Riboflavin (as riboflavin 5# - phosphate sodium) - 15.00 mg

Niacin (as niacinamide and niacin) - 48.00 mg

Vitamin B6 (as pyridoxal 5# - phosphate) - 15.00 mg

Folate (100 mcg as Quatrefolic® (6S)-5-methyltetrahydrofolic acid, glucosamine sale and 100 mcg as calcium folinate) - 300.00 mcg

Vitamin B12 (as MecobalActive# methylcobalamin) - 375.00 mcg

Biotin - 750.00 mcg

Pantothenic Acid (as d-calcium pantothenate) - 150.00 mg

Iodine (as potassium iodide) - 74.00 mcg

Magnesium (as Albion® di-magnesium malate) - 75.00 mg

Zinc (as TRAACS® zinc bisglycinate chelate) - 9.75 mg

Selenium (as Albion® selenium glycinate complex) - 75.00 mcg

Copper (as TRAACS® Copper Glycinate Chelate) - 0.75 mg

Manganese (as TRAACS® manganese bisglycinate chelate) - 0.38 mg

Chromium (as TRAACS® chromium nicotinate glycinate chelate) - 575.00 mcg

Molybdenum (as TRAACS® molybdenum glycinate chelate) - 37.50 mcg

Potassium (as Albion® potassium glycinate complex) - 74.25 mg

Choline (as choline dihydrogen citrate) - 27.00 mg

Alpha Lipoic Acid - 200.00 mg

American Ginseng Extract (Panax quinquefolius)(root and leaf)(15% ginsenosides) - 375.00 mg

Cinnamon 10:1 Aqueous Extract (Cinnamomum cassia)(bark)(3% type-A polymers)(CinSulin®) - 200.00 mg

EVNol SupraBio# Bio-Enhanced Natural Full Spectrum Tocotrienol/Tocopherol Complex - 164.50 mg

Green Tea Aqueous Extract (Camellia sinensis)(leaf)(80% polyphenols, 60% catechins, 30% EGCG, 6% caffeine) - 200.00 mg

Gymnema Extract (Gymnema sylvestre)(leaf)(25% gymnemic acids) - 200.00 mg

Inositol -27.00 mg

PABA (para-aminobenzoic acid) - 9.75 mg

Total Mixed Tocopherols - 125.00 mg

Vanadium (as TRAACS® vanadium nicotinate glycinate chelate) - 562.50 mcg

Other Ingredients:

Ultimate E - Sunflower oil, softgel (bovine gelatin, vegetable glycerin, and purified water), and polyglycerol esters of fatty acids.

Glycemic Factors - HPMC (capsule), microcrystalline cellulose, stearic acid, magnesium stearate, silica, and medium-chain triglycerides.

Multi w/o Iron - HPMC (capsule), microcrystalline cellulose, ascorbyl palmitate, silica, and medium-chain triglyceride oil.

Allergy Information:

May contain fish, shellfish, egg, soy, milk, and tree nuts.

Adverse Reactions

Biotin – There are no known adverse reactions with proper supplementation.

Calcium – Taking calcium without food may increase the risk of kidney stones. Mild upset stomach has been reported with calcium supplementation.

Choline – Nausea, diarrhea and dizziness may occur in large doses.

Chromium – There are no known adverse reactions with proper supplementation.

Inositol – Pregnant women should avoid inositol, as it may stimulate uterine contractions.

Magnesium – Diarrhea, nausea, or abdominal cramping have been reported in large doses. Pregnant women and nursing mothers should not take doses greater than 350 mg per day of magnesium. Individuals with myasthenia gravis should not take magnesium.

Manganese – Individuals with liver or kidney ailments should not take manganese.

Molybdenum – Individuals with gout or hyperuricemia should avoid doses greater than 75 mcg.

Niacin – Up to 2 g per day

Pantothenic Acid – Diarrhea may occur in large doses.

Riboflavin – High doses of Riboflavin (400 mg per day) can cause diarrhea and polyuria.

Selenium – Pregnant women and nursing mothers should avoid taking doses greater than the RDA amount of selenium (60 to 70 mcg per day). Excessively high doses of selenium can lead to dry hair, brittle nails, fatigue, irritability, nausea, and vomiting.

Thiamin – Pregnant women should avoid doses of thiamin greater than 3 mg per day.

Vitamin A – Pregnant women and nursing mothers should avoid vitamin A doses higher than 5,000 IU per day. High doses (greater than 10,000 IU per day) of vitamin A can cause acute or chronic toxicity.

Vitamin B6 – High doses of vitamin B6 can cause nausea, abdominal pain, vomiting, loss of appetite, and breast soreness.

Vitamin B12 – Individuals with Leber’s disease (eye problems) should not use.

Vitamin C – Stomach upset including nausea, diarrhea, abdominal cramps may occur in large doses due to unabsorbed vitamin C passing through the intestines.

Vitamin D3 – Do not take vitamin D if you have lupus. Pregnant women and nursing mothers should avoid supplementing with doses higher than the RDA amount (400 IU), unless prescribed by a physician. Research indicates that the RDA amount of vitamin D is not enough to meet all of your body’s needs. To lower health risks associated with vitamin D deficiency, optimal levels may be reached by taking 1000 IU/day.[xxi] Though optimal amounts of vitamin D may seem high in comparison to the RDA standard, studies have found vitamin D toxicity is unlikely to occur in doses less than 10,000 IU (250 mcg)/day.[xxii],[xxiii]

Vitamin E – Stomach upset may occur in large doses. Individuals with blood clotting ailments or high blood pressure should consult their physician prior to supplementation. Pregnant women and nursing mothers should not take doses higher than the RDA amounts (15 mg or 22.4 IU). Excessive amounts of vitamin E may cause an upset stomach, headache, fatigue, or blurred vision.

Drug Interactions

Consult your physician before supplementing with Comprehensive Formula if you are taking the following medications.

Biotin – Antibiotics, Anticonvulsants

Calcium – Bisphosphonates, H2 blockers, Levothyroxine, Proton pump inhibitors, Quinolones, Tertracyclines, Vitamin D Analogues.

Choline – Methotrexate

Chromium – Beta-Blockers (may elevate cholesterol levels)

Magnesium – Bisphosphonates, Quinolones, Tetracyclines

Manganese – Antacids, Laxatives, Tetracycline

Molybdenum – Acetaminophen

Inositol – There are no known interactions with proper supplementation.

Niacin – Alpha-blockers; Alpha-glucosidase inhibitors; Anti-diabetic medications; Calcium channel blockers; Cholestyramine; Colestipol; Coumadin (Warfarin); Ganglionic blocking agents; Gemfibrozil; Nicotine patch; Nitrates; NSAIDS; Statins.

Pantothenic Acid – There are no known interactions with proper supplementation.

Riboflavin – Cholestyramine, Chlorpromazine, Colestipol, Doxorubicin, Metoclopramide, Nucleoside reverse-transcriptase inhibitors, Oral Contraceptive Agents, Probenecid, Propantheline Bromide, Quinacrine, Tricyclic Antidepressants

Thiamin – Loop diuretics (furosemide, ethacrynic acid, bumetanide)

Vitamin A – Cholestyramine, Colestipol, Mineral Oil, Oral Contraceptives, Orlistat, Retinoid Drugs

Vitamin B6 – Amiodarone, Carbamazepine, Cycloserine, Ethionamide, Fosphenytoin, Hydralazine, Isoniazid, Levodopa, Oral Contraceptives, Penicillamine, Phenelzine, Phenobarbital, Phenytoin, Theophylline, Valproic acid.

Vitamin B12 – Antibiotics, H2 blockers, Aminosalicylic Acid, Metformin, Nitrous oxide, Proton pump inhibitors (omeprazole, etc.) may all decrease vitamin B12 absorption.

Vitamin C – Aluminum-containing antacids, Aspirin (impairs vitamin C), Chemotherapeutic agents, Estrogen, or Indinavir.

Vitamin D3 – The following drugs may reduce vitamin D absorption: Orlistat; Cholestyramine; Ketoconazole; Colestipol; Phenobarbital; Phenytoin; Antacids with aluminum.

Vitamin E – Anticoagulants (Warfarin), Amiodarone, Anticonvulsants, Colestipol, Cyclosporine, Isoniazid, Neomycin, Orlistat, Sucralfate, Zivudine.

Zinc – Antibiotics block zinc absorption

Healthy Aging

Individuals need an adequate intake of vitamins and minerals to maintain important body functions. A balanced ratio of nutrients can be obtained through multivitamins; yet, studies have found most individuals do not receive the optimal amount of vitamins that are necessary for overall health.[i] Additionally, it is suggested that more physicians need to educate their patients on the importance of taking a quality multivitamin.[i]

Vitamin deficiencies can lead to many health ailments, especially among older adults. One study explained that older women taking vitamins, in combination with exercise and hormone therapy, lessened the development of health ailments.[ii]

An eight-week study reviewed the effects of a multivitamin or a placebo on the micronutrient status of 80 healthy, older adults (50 to 87 years old). Results indicated that a multivitamin increased the micronutrient status in the treatment group to reduce various health risks.[iii]

Furthermore, vitamins can deter the effects of aging skin. A research review explained that vitamin supplementation enhanced immunity in the skin to reduce inflammation and signs of aging. [iv]

Cardiovascular Health

A longitudinal study examined the relationship between low vitamin intake and cardiovascular ailments among 80,082 healthy women. After fourteen years, the follow-up indicated women that regularly took a multivitamin had the lowest risk for cardiovascular ailments. Folate and vitamin B6, found in the multivitamin treatment, were suggested to be particularly important to cardiovascular health.[v]

A large survey evaluated multivitamin use among 21,923 participants. The study found that one-third of the individuals took dietary supplements, in which individuals taking vitamins and minerals had fewer cardiovascular risks.[vi]

Cellular Health

Individuals that receive adequate amounts of vitamins, minerals, fiber, and essential fatty acids are 60-70% less likely to develop abnormal cell growth in the breast, colon or prostate. Furthermore, optimum levels of nutrients decrease the risk of lung disorders by 40-50%.[vii]

A longitudinal study evaluated vitamin B6 and folate intake in relation to colon health among 37,916 healthy women. After ten years, researchers found that women taking optimum levels of vitamin B6 and folate were less likely to develop colon ailments, as women that did not take these nutrients were at significant risk for developing abnormal cell growth in the colon.[viii] A similar longitudinal study that recruited 88,756 healthy women found that individuals taking a multivitamin had fewer colon risks. Researchers concluded these effects could be specifically associated with the folic acid content that is found in multivitamins.[ix]

Individuals that receive adequate amounts of vitamins, minerals, fiber, and essential fatty acids are 60-70% less likely to develop abnormal cell growth in the breast, colon or prostate. Furthermore, optimum levels of nutrients decrease the risk of lung disorders by 40-50%.[vii]

Weight Management

A cross-sectional survey found that multivitamin intake was related to body weight, as overweight individuals were less likely to take a multivitamin. Individuals with normal body weight recognized the importance of taking a multivitamin to maintain overall health.[x] Another study found that body mass was associated with micronutrient levels. Overweight adults had low micronutrient levels, when compared to normal weight individuals.[xi]

Research between multivitamin use and weight has been extended to improving infant birth weight. One study recruited pregnant women in poor communities to take a prenatal multivitamin, finding the nutrients lowered a woman’s risk of giving birth to an underweight infant. Therefore, the prenatal multivitamin improved an infant’s life expectancy.[xii]

Another study found that multivitamin supplementation contributed to weight gain in pregnant women with autoimmune ailments in sub-Saharan Africa. Researchers recruited 1,075 pregnant women to take a multivitamin, multivitamin with vitamin A, vitamin A alone, or a placebo. Results indicated weight gain was significantly greater among women taking a multivitamin during pregnancy, especially among subjects taking the multivitamin/vitamin A combination.[xiii]

Energy/Muscle Performance

As individuals age, muscle often deteriorates. Researchers suggest that a healthy diet, vitamin supplementation, and regular physical activity can inhibit the loss of muscle mass and strength that is commonly found in the aging population.[xiv]

One study recruited athletes to take a vitamin and mineral supplement or a placebo prior to and during an extreme running competition. Researchers found that athletes taking the multivitamin had greater nutrient values in their blood serum and lower levels of lipid peroxidation (oxidative stress) that is associated with intense athletic training.[xv]

Immune Function

Multivitamins can improve the immune response and overall physical health by increasing micronutrient availability.[xvi] One study recruited 1,078 pregnant women in sub-Saharan Africa with autoimmune ailments to take a multivitamin finding the supplement increased their immunity and deterred the effects of their autoimmune illness.[xvii]

A one-year study recruited 130 individuals with blood sugar ailments to take a daily multiple or a placebo, reporting a multivitamin reduced the incidence of infection among subjects in the treatment group. A multivitamin also reduced micronutrient deficiencies in the treatment group.[xviii]

Emotional Health

Several nutrients contained in a daily multiple have been found to support emotional health. A six-month study gave a probiotic multivitamin or a placebo to 42 adults with stress and fatigue. Results indicated the supplement reduced exhaustion and the stress response, along with improving the immune system.[xix]

Furthermore, one study evaluated the relationship between a daily multiple and mood improvement. Researchers recruited 225 elderly patients with an acute illness and low mood to take a multivitamin or a placebo, finding the treatment group had a significant improvement in mood, as vitamin B12 serum levels increased in this group.[xx]

[i] Fletcher RH, Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications. JAMA. 2002 Jun; 287(23):3127-3129.

[ii] La Croix A, Newton K, Leveille S, Wallace J. Healthy aging: A woman’s issue. West J Med. 1997 October; 167(4):220–232.

[iii] McKay D, Perrone G, Rasmussen H, Dallal G, et al. The effects of a multivitamin/mineral supplement on micronutrient status, antioxidant capacity and cytokine production in healthy older adults consuming a fortified diet. Journal of the American College of Nutrition. 2000; 19(5):613-621.

[iv] Boelsma E, Hendriks FJ, Roza L. Nutritional skin care: health effects of micronutrients and fatty acids. American Journal of Clinical Nutrition. 2001; 73(5):853-864.

[v] Rimm E, Willett W, Hu F, Sampson L, Colditz G, et al. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA. 1998; 279:359- 364.

[vi] Harrison R, Holt D, Pattison D, Elton P. Are those in need taking dietary supplements? A survey of 21,923 adults. British Journal of Nutrition. 2004; 91(4):617-623.

[vii] Donaldson M. Nutrition and cancer: A review of the evidence for an anti-cancer diet. Nutr J. 2004; 3:19.

[viii] Zhang S, Moore S, Lin J, Cook N, et al. Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women. Am J Epidemiol. 2006; 163(2):108-115.

[ix] Giovannucci E, Stampfer M, Colditz G, Hunter D, et al. Multivitamin use, folate, and colon cancer in women in the Nurses’ Health Study. Annals of Inter Med. 1998; 129(7):517-524.

[x] Kimmons J, Blanck H, Tohill B, Zhang J, et al. Multivitamin use in relation to self-reported body mass index and weight loss attempts. MedGenMed. 2006; 8(3):3.

[xi] Kimmons J, Blanck H, Tohill B, Zhang J, et al. Associations Between Body Mass Index and the Prevalence of Low Micronutrient Levels Among US Adults. MedGenMed. 2006; 8(4):59.

[xii]Scholl T, Hediger M, Bendich A, Schall J, et al. Use of Multivitamin/Mineral Prenatal Supplements: Influence on the Outcome of Pregnancy. Am J Epidemiol. 1997; 146:134-141.

[xiii] Villamor E et al. Effect of multivitamin and vitamin A supplements on weight gain during

[xiii] Villamor E et al. Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women. American Journal of Clinical Nutrition, 2002; 76:1082-1090.

[xiv] Roubenoff R. Physical Activity, Inflammation, and Muscle Loss. Nutrition Reviews. 2007; 65(3):s208-s212.

[xv] Machefer G, Groussard C, Vincent S, Zouhal H, et al. Multivitamin-Mineral Supplementation Prevents Lipid Peroxidation during “The Marathon des Sables”. Journal of the American College of Nutrition. 2007; 26(2):111-120.

[xvi] Bendich A. Micronutrients in women’s health and immune function. Nutrition. 2001; 17(10): 858–867.

[xvii] Fawzi WW, Msamanga GI, Spiegelman D, et al. A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med. 2004; 351(1):23-32.

[xviii] Barringer T, Kirk J, Santaniello A, Foley K, Michielutte R. Effect of a Multivitamin and Mineral Supplement on Infection and Quality of Life. Annals of Intern Med. 2003; 138(5):365-371.

[xix] Gruenwald J, Graubaum H, Harde A. Effect of a probiotic multivitamin compound on stress and exhaustion. Advances in Therapy. 2002; 19(3):141-150.

[xx] Gariballa S, Forster S. Effects of dietary supplements on depressive symptoms in older patients: A randomised double-blind placebo-controlled trial. Clin Nutr. 2007; 26(5):545-551.

[xxi] Garland C, Garland F, Gorham E, et al. The role of vitamin D in cancer prevention. Amer J of Pub Health. 2006; 96(2):252-261.

[xxii] Peacock, M, Liu, G, Carey, M, et al. Effect of calcium or 25OH vitamin D3 dietary supplementation on bone loss at the hip in men and women over the age of 60. J Clin Endocrinol Metab. 2000; 85: 3011-3019.

[xxiii] Hollis, BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. 2005; 135: 317-322.